How bacteria-produced protein causes disease? Scientists have discovered how these proteins enabled the disease-causing pathogens to stick to human cells.
All bacteria contain a standard secretion system that lets them to transmit different types of proteins outside of their cells.
Adhesins is the essential class of extracellular molecules pathogenic bacteria-produced proteins which allows bacteria to stick to host cells. The scientists found that the SRR (serine-rich-repeat) adhesins of Staphylococcus and Streptococcus bacteria are exported through a secretion pathway that is similar to the standard system. These bacteria can cause serious infections such as bacterial meningitis, bacterial pneumonia and pericarditis. Who led this study, tried to understand the actual working of these dedicated molecular supply chains.
“I was intrigued by the fact that there is a second secretion system in some bacteria that is separate from the canonical secretion system and is just dedicated to the secretion of one protein,” said a professor at Harvard Medical School in the US, Tom Rapoport.
Rapoport also added, “There is a whole machinery, and it’s only doing one thing.”
Though the real fact that these bacteria use this separate transport pathway for adhesins is difficult to find, the new findings of this pathway’s components may help researchers develop highly targeted antibiotics in the future to treat infections caused by these bacteria. These findings which identified how bacteria-produced protein causes disease may help in the development of novel antibiotics.
“You could imagine that you could develop novel antibiotics that could target this pathway. They would be very specific for pathogenic bacteria,” Rapoport said.