Common DNA mutation occurrence

Common DNA mutation occurrence is not a fictional representation but actually functioning in our DNA. Researchers elucidate how two incompatible bases in human DNA are able to alter shape in order to circumvent the body’s inherent defenses against genetic mutations. Guanine and thymine are able to alter shape in order to configure unnoticeable rung on the helical DNA ladder.


Zucai Suo, professor of chemistry and biochemistry at The Ohio State University and co-corresponding author of the study said that when these two bases form a hydrogen bond by mischance, they don’t fit appropriately initially. They are extremely noticeable along the DNA Helix, so usually it’s simple for the enzymes that reproduce DNA to reveal them and fix them. But sometimes before they can be revealed, they alter shape. It’s almost as if two bases are able to connect to each other so they can adjust like normal base pair and avoid DNA repair mechanisms.

Suo said, “They’re bad guys, but they pretend to be good guys to survive.” The finding furnishes a base for work on other kinds of DNA mutations which are a trigger for diseases, normal aging and even evolution. The four foundations of DNA each possess their own size and shape and are presumed to adjust together in just a right way. Adenine (A) is always supposed to pair with thymine (T), and cytosine (C) is always supposed to pair with guanine (G). The two “Watson-Crick” base pairs, A-T and C-G, form the DNA sequences of all life. But if G were to mismatch with T, for example, that would be a mutation.

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